Monoclonal antibody to a novel lymphocyte function-associated antigen (LFA-1): mechanism of blockade of T lymphocyte-mediated killing and effects on other T and B lymphocyte functions.
نویسندگان
چکیده
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منابع مشابه
By Francisco Sanchez - Madrid , Janice a . Nagy , Elizabeth Robbins , Paul Simon , and Timothy
Two human molecules with surprisingly similar molecular structures, LFA-1 and Mac-1/OKM1, have recently been found to be important in cytolytic T lymphocyte-mediated killing, and in complement receptor function, respectively. Human LFA-1 contains two subunits of Mr 177,000 and 95,000 (1), and OKM 1/ Mac-1 (2) has two polypeptides of strikingly similar size. Monoclonal antibodies (MAb) to human ...
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ورودعنوان ژورنال:
- Journal of immunology
دوره 127 2 شماره
صفحات -
تاریخ انتشار 1981